Korean Journal of Nephrology 1984;3(2):191-197.

본태성고혈압 및 만성신부전에서 요 Prostaglandin E 의 의의 (義意)

서상렬 , 변관수 , 남궁호삼 , 김형규 , 흥순국

Abstract

In order to define tke changes of urine prosta- glandin E in chronic renal failure, urine excre-tion of prostaglandin E, was measured ' in 24 normal control group, in 23 essential hypertension not associated with renal impairment, and in 25 chronic renal failure associated witn hypertension of which creatinine clearance was below 20 ml/ min. Otherwise serum and urine sodium, serum creatinine and creatinine clearance were measu- red. The results obtained are as follows; 1) The value of urine prostaglandin E, in nor- mal control group is 367.1±168.24(mean S.D.) pg/ml., in essential hypertension 350.4±97.32 pg/ ml. And in chronic renal failure with hyperte nsion 84. 5±40. 76 pg/ml. Respectively. In chronic renal failure group, urine prostaglandin E, is significantly lower than in normal control group (P<0. 01). 2) Urine prostaglandin E, has no significant relation to diastolic blood pressure, serum and urine sodium and creatinine clearance in each group. 3) Urine prostaglandin E, is not reIated to sex and age distribution. In our results, it is cansidered that the decrease of urine prostaglandin E in chronic renal failure is accompanied by the progressrve reduction of renal functioning mass.