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급성신부전 환자에서 필수아미노산 정맥투여 효과 |
정현철 , 손영진 , 박성배 , 권오선 , 임천규 , 김명재 |
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Abstract |
'The present study was done to evaluate the therapeuric effect of infusicn in patient with ARF from Jan. 1981 to June 1985 and compared ARF her".cdialyzed group with essential amino acid. The results was summarized as follows." 1) Mean dur ation of oliguria among those sur- viving the episode of acute renal failure was 3.92±0.87 days in the amino acids group(group I) and 4.24±0. 47 days in the control group(group II ) in the hemodialyzed patients, but without statis- tical significance. 2) Mean duration of rising serum creatinine was 5 57 ±0. 93 days in the amino acids group (group I ) and 6. 63±0. 85 days in the control group(group III) in the hemodialyzed patients (p<0. 005). 3) Peak level of mean blood urea nitrogen and mean serum serum potassium during treatment was significantly lower in the amino acid group (group I ) than tho e in control grop(group II ) respectively(p(Q. 005). 4) Fr equencies of dialysis were significantly lower in the amino acids group(group,I ) than those in the control groups(group II ) in the he- modialyzed patients(4. 63±0. 71 vs 5. 69±0. 54, P( 0. 005). 5) The overall mortality rate of acute renal failure was 34.29%. EH fever(16%') and drug intoxication(16%) were the most common causes of expired patients even with dialysis. 6) The mortality rate was reduced from 37. 5% in the control group(group II) to 6.25%' in pati- ents who received amino acids(group I ) in hem- odialyzed group. Therefore, recovery of renal function appeared to be hastened by essential amino acids, and it might be associated with beneficial changes in nitrogen metabolism. Because of the improved survival observed in the study, it seemed reasonal to advocate the use of its treatment mode in most patients with ARF. |
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