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| 성인 미세변화 신증후군의 임상성 및 치료성적 |
| 김영수 , 서원교 , 이태원 , 임천규 , 김명재 |
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| Abstract |
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Minimal change disease (MCD) is a common cause of nephrotic syndrome. The clinical features and therapeutic response of MCD in childhood were well studied but not in adults. We reviewed 48 adult-onset nephrotic patients with a minimal change histology in Kyung Hee University hospital from 1980 to 1986 and the following results were obtained. 1) MCD is the most common cause of the adult-onset nephrotic syndrome in our hospital. 2) Hypertension (BP >140/90) was observed in 27% of patients, microscopic hematuria (RBC >=3 in HPF) in 77 % and transient renal functional impairement (s-Cr. >= 1. 5 mg/dl) in 35%. 3) With corticosteroid therapy, complete remission was obtained in 81% of the daily treated group, 83% of the alternate day therpay group and 77% of the combi- nation therapy group. 4) During the follow up period of one year, 27% of the daily therapy group, 40% of the alternate day therapy group and 30% of the combination therapy group were still in remission. 5) With combination therapy, 67% of the patients with steroid resistant or frequent relapsing MCD went into complete remission. |
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