|
| 고출혈성 요인 환자에서 Gabexate Mesilate 하응고제로 이용한 혈액 투석 |
| 정동국 , 서홍석 , 권영주 , 위경소 , 김형규 , 김정숙 |
|
|
| Abstract |
|
Anticoagulation with heparin is necessary during hemodialysis to prevent clotting in the extracorporeal circulation. It has been reported that the incidence of clinically important hemorrhage has occurred about 10 to 30% undergoing hemodialysis patients. By the way, regional heparinzation, commonly used at present in the high-risk bleeding patients, has some disadvantages. Therefore, we successfully performed 8 times hemo- dialysis using Gabexate mesilate, a potent synthetic proteinase inhibitor, as the anticoagulant instead of heparin in the patients suffered from chronic renal failure with huge intracerebral hemorrage and primary hepatoma, ruptured into the peritoneal cavity with secondary renal failure. We administered the Gabexate mesilate at the doses of 1000-1500 mg/hr into the arte- rial line of dialyzer. During hemodialysis, the coagula- tion studies were not changed as those of prehemodi- alysis, which were within normal limits. And we couIdn' t find any adverse effect of Gabexate mesilate. In conclusion, Gabexate mesilate anticoagulation is rather convenient and safe method of hemodialysis in the high-risk bleeding CRF patients. |
|
PDF Links
Download Citation
