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| Renin Heterogeneity와 생리적인 특성에 관하여 |
| 김선희 , 고규영 , 설경환 |
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| Abstract |
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It is well established that the renin-angiotensin system (RAAS} is important as a key role in the regulation of blood pressure and fluid balance. With the development of techniques for protein purification, extensive studies have been focused on chemical characterization of renin. Renin heterogeneity such as active and inactive renin, different molecular weights of renin, and different forms of renin with different isoelectric points (pIs), has been described in many species. It was also found that changes in renin heterogeneity are associated with altered salt and water balance and high blood pressure. The ratio of active and inactive renin was changed by acute stimulation of RAAS such as diuretics, converting enzyme inhibitors and low salt intake and by a certain kinds of disease such as diabetes mellitus and hyperten- sion. Multiple forms of renin with different pIs had different half-lives and quantitatively different effects on renal function. The relative proportion of these forms has been modified in response to beta-agonist, calcium channel blocker, low salt diet, and renal arterial constriction; they characterized by an increase in pro- portion of renin forms which have more acidic pIs and longer half-lives. It was suggested that the renin heterogeneity may be of functional significance related to the regulation of renal function and blood pressure eventhough the exact mechanisms are still unknown. |
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