Korean Journal of Nephrology 1988;7(1):8-17.
마취된 고양이에서 발물에 의한 Reno - Renal Feflex의 과 이의 에 대한
정임수
Abstract
The present study was designed to investigate the characterization of the reno-renal reflex and its phar- macological role on the renal function when induced by the stimulation of renal chemoreceptors with algogenic substances (capsaicin and bradykinin) and high concen- tration of NaCl. 1) When capsaicin (1.0 and 2.0 mg) was injected through intrarenal artery, not only the ipsilateral renal afferent nerve activity but also ipsilateral and contra- lateral renal efferent nerve activities were simul- taneoulsy increased in accordance with an increase in systemic arterial pressure. Bradykinin was injected through intrarenal artery elicitied an increase in ipsila- teral and contralateral renal efferent nerve activity but not in afferent nerve activity. 2) Intrarenal injection of high concentration of NaCl(1.0 M) solution elicited an increase in both ip- silateral renal afferent nerve and efferent nerve activ- ities without producing an increase in the contralateral renal efferent nerve activity. 3) Following right renal nerve denervation, the in- creased ipsilateral and contralateral renal efferent nerve activities in response to algogenic substances were abolished. The change in systemic arterial pres-sure was not observed. 4) In renal function studies, intrarenal injection of capsaicin (2.0 mg) significantly decreased the urinary sodium excretion in association with urine volume. However, the renal blood flow, glomerular filtration rate and potassium excretion rate were not altered. Nevertheless, bradykinin injection did exert little alterations in renal function. Otherwise, NaCl (1.0 M) decreased both urine volume and sodium excretion. 5) In comparative studies, intrarenal injection of cap- saicin evoked the increase in cervical and splenic sympathetic efferent nerve activities, however, the ratio of splenic/renal nerve activities was less than that of cervical/renal. Intrarenal injection of bradykinin yield- ed only the cervical sympathetic activiation without affection on the splenic nerve activity. Based on these results, it was speculated that upon stimulation of renal chemoreceptors by intrarenal injec- tion of capsaicin, the reno-renal reflex was produced in concert with antinatriuresis and antidiuresis as well as that induced by high concentration of NaCl. Thereby, it may be suggested that this reflex plays an important role in the regulation of renal function.
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