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| Cuprophane막을 이용한 혈액투석에서 혈중 보체의 활성화 |
| 한진석 , 김윤권 , 김성권 |
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| Abstract |
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Various cardiopulmonar symptoms have ocured dur- ing the first 15 to 30 minutes of hemodialysis. The decreased leukocyte counts and arterial oxygen tension during the same phase has been reported, but its exact mechamism is under debate. To investigate the relationship between the above phenomena and the activiation of complement, we per- formed serial measurements of arterial blood gas analy- sis, leukocyte counts and plasma complement during hemodialysis in the 6 patients with the stable chronic renal failure. 1) The plasma levels of C,a desArg were singificantly elevated at 15 minutes of hemodialysis and returened to normal within 4 hours. C,a desArg did not change signif- icantly during hemodialysis. The pleak plasma levels of C,a desArg were noticed at 1S to 30 minutes and gradu- ally returned to normal. 2) The major fall of total leukocyte counts occurred during the first 15 to 30 minutes, then gradually returned to normal within 4 hours. 3) Comparison of leukocyte counts with the corre- sponding C,a desArg at each time had highly significant relationship (r=0.72). 4) The major fall of arterial oxygen tension occurred during the first 30 minutes and it gradually increased but persisted still lower level at the end of hemodialysis. Thus we concluded that decreased leukocyte counts and arterial oxygen tension during the early phase of hemodialysis may be related with complement activa- tion via alternative pathway. |
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