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| 만성 신부전 환자에서 복막투석시 Polyamine의 변동 |
| 김병수 , 김용섭 , 권용주 , 조원용 , 김형규 |
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| Abstract |
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Polyamine, which are organic cations that play var- ious roles in normal cellular proliferation and differentiation, accumulate in plasma and body fluid of patients suffering from chronic renal failure and have been regarded as uremic toxin. The authors evaluated the effect of peritoneal dialysis on plasma and per- itoneal levels of polyamines in 5 patients with chronic renal failure undergoing continuous ambulatory per- itoneal dialysis (CAPD). The results were as follows: 1) In patients with chronic renal failure on CAPD, predialysis plasma levels of putrescine, spermidine and spermine were 3.8±2.37, 0.72±0.07, and 0.83±0.53 nmol/ ml, respectively. The plasma levels of putrescine, sepr- midine and spermine were 1.29±0.17, 0.49± 0.15 and l. 59±1.38 nmol/ml in normal subjects. 2) During peritoneal dialysis, there were no significant changes of plasma and dialysate polyamine levels. The plams levels of spermine and spermidine decreased to 0.16+0.12 nmol/ml and 0.10±±0.11 nmol/ ml at 120 min after initiation of peritoneal dialysis. 3) Ther were no significant correlation between chan- ges of serum and dialysate creatinine and changes of plamsa and dialysate polyamine. From the above findings, it was suggested that the predialysis levels of plasma polyamine in patients with chronic renal failure on CAPD were elevated and that polyamines were not dialysable with peritoneal dialysis. |
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