Korean Journal of Nephrology 1990;9(4):527-535.

신장이식 100예의 임상적 고찰

박성배 , 김현철 , 조원현 , 박철희 , 김천일 , 우성구 , 전석길 , 전동석 , 김재룡

Abstract

The 100 cases of living-donor renal transplantation experience at the Keimyung University Hospital be- tween November 1982 and August 1989 was reviewed. The overall 1 and 3 year patient survival rates were 95. 5% and 92.1%, and the corresponding graft survival rates were 89.6% and 79% respectively. Acute rejection occurred in 34 cases. According to HLA match, acute rejection occurred in 8.3% of HLA-identical group, in 31. 3% of haploidentical, and in 57.9% of mismatched/ unrelated groups. Reversibility was 100%, in HLA identical group, 90.5%; in haploidentical, and 83.3% in mismatched/unrelated group. There were eight deaths, and the causes of death were pneumonia in 2, heart failure in 2, sudden death in 2, bowel infarction in 1, and intracerebral hemorrhage in 1. The 18 patients lost their grafts because of chronic rejection in 7, acute rejection in 3, renal artery thrombosis in 2, recurrent glomerulone- phritis in 1 and death with functioning grafts in 5. Surgical complications was found in 22 cases, among surgical compications there were 11 perirenal hematoma, 4 transient hydronephrosis, 2 ureteral ob- struction, 2 lymphocele, 2 renal artery thrombosis, and 1 kidney fracture. Among the infectious complications, bacterial and viral infections were the most common organisms occuring in 57.4% and 31.5%, respectively. Urinary tract infection was the most common cause of bacterial infections. In the non-infectious complications, the most frequent were hyperkalemia (25%), hyperten- sion(20%), erythrocytosis(9%), diabetes mellitus(6%), avascular necrosis of femoral head(5%), and acute tubular necrosis(3%). The most common side effects of cyclosporine-A were tremor and hirsutism in 63.8%, nephrotoxicity 13.8%, diarrhea 6.4% and gum hypertro- phy 4.3% of the patients.