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| 소아에서 1회뇨 단백 / 크레아티닌 비를 이용한 요단백의 정량에 관하여 |
| 최성민 , 김범준 , 고철우 , 구자훈 |
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| Abstract |
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A prospective study was conducted to determine the correlation of random urinary protein/creatinine ratio to 24-hour urinary protein excretion. Study patients consisted of 45 children without renal disease (age 2-14 years, Group I) and 13 children with nephrotic syndrome (Group II; 10 minimal change nephrotic syndrome, 1 mesangioproliferative glomerulonephritis and 2 end- stage renal disease). Random urine sample at 7:00 A.M., 3:00 P.M. and 24-hour urine sample were collected for determination of urinary protein/creatinine ratio and 24-hour urinary protein excretion. And following results were obtained. In Group I (children without renal disease), random urinary protein/creatinine ratio (Up/Uc, mg/mg) was 0. 09±0.09 at 7:00 A.M., 0.09±0.11 at 3:00 P.M.. In Group II (children with nephrotic syndrome). The Up/Uc was 4. 17±3.68 at 7:00 A.M., 4.85± 4.83 at 3:99 P.M., and 24-hour urinary protein excretion was 2346.0±3229.0 mg/M/ day; the correlation with Up/Uc at 7:00 A.M. was highly significant (r=0.78, p<0.01). The accepted nephrotic level of proteinuria, 40 mg/hr/M, coincides with the Up/Uc of 1.78 at 7:00 A.M. and 2.07 at 3:00 P.M.. In conclusion, random urinary Up/Uc is a simple and fairly accurate test for 24-hour urinary protein excre- tion, and could be used safely for the assessment of degree of proteinuria in children. |
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