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| 소아 신증후군의 재발시 Albumin - Lasix 혈청 요법이 Atrial Natriuretic Peptide 및 Aldosterone 에 미치는 영향 |
| 한창희 , 최성민 , 고철우 , 구자훈 , 이원정 |
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| Abstract |
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During nephrotic crisis, albumin-lasix therapy has been utilized frequently for the control of oliguria com- bined with severe edema. Present study was conducted to see the change of volume status induced by albumin- lasix therapy in children with nephrotic crisis. Serum ANP and aldosterone were determined by RIA method before, during and after albumin-lasix infusion. Study patients consisted of 9 children with nephrotic crisis (8 minimal change nephrotic syndrome, 1 membrano- proliferative glomerulonephritis), and following results were obtained. All patients showed brisk diuresis after albumin-lasix infusion therapy. After albumin infusion, serum ANP rose to 70.17±50,66 pg/ml from free infusion level of 18. 48±14.97 and this increased level persisted up to 3 hours after lasix infusion. Serum aldosterone level after albu- min infusion decreased to 44.77±37.45 ng/ml from free infusion level of 166.85±150.11, and this decreased level also persisted upto 3 hours after lasix infusion. These changes of ANP and aldosterone showed statistically significant difference (p<0.05). In summary, present study demonstrates that albumin-lasix therapy is effective treatment modality in severe nephrotic crisis without hazardous changes of volume status in pateints. |
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