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신증후군 환자의 골밀도 및 스테로이드 치료후의 골미도 변화 |
김세윤 , 김영훈 , 이태원 , 임천규 , 김명재 |
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Abstract |
T-cell dysfunction is postulated as pathogenesis of idiopathic nephrotic syndrome. Cyclosporin A has high- ly selective immune suppressive action by inhibition of the production of interleukin 2 by helper T-cells. We tried cyclosporin A for 8 weeks combined with alternate day prednisolone therapy in 4 steroid resistant patients and 16 steroid dependent patients, and followed for 9 months to 36 months (mean 18 months.). All patients responded to cyclosporin A, but relapse was observed in 6 (37%.) among the 16 steroid dependent patients and in 2 (50%.) among the 4 steroid resistant patients, mean relapse rate was 40%. The mean age of the patients who relapsed after cyclosporin A treatment was 6.5 years and who did not relaspse was 10.9 years at the beginning of Cy A trial. Cyclosporin A is effective in response induction in nephrotic syndrome but 8 weeks trial of cyclosporin A does not seem to be effective in prevent- ing the replase. And also age factor must be considered when considering a trial of cyclosporin-A although childhood idiopathic nephrotic syndrome has a tendency of spontaneous regression after puberty. |
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