Korean Journal of Nephrology 1993;12(4):566-572.

신증후군 환아에서 T - 임파구 아집단에 관한 연구

이종광 , 유기환 , 김순겸

Abstract

The etiology of steroid responsive nephrotic syn- drome (SRNS) remains unclear, but T--lymphocyte subsets when measured in steroid responsive nephrotic syndrome have demonstrated significant variance from normal values. We evaluated lymphocyte subsets in children with nephrotic syndrome. The children were divided into five groups: I) SRNS in acute relapse, on prednisone, II) SRNS in acute relapse, off prednisone, III) SRNS in long-term remis- sion, off prednisone, IV) patients in remission on long- term prednisone therapy, V) patients with nephrotic syndrome of recent onset and IV) 17 normal controls. The results obtained were as follows: 1) Total T cell counts showed no changes between study group and control, except patients group in remis- sion on long-term prednisone therapy, Total T cell counts in group IV were increased (p<0.05). 2) T helper cell was decreased in patients with SRNS in acute relapse, on prednisone (group 1) when compared to normal controls (p<0.05). 3) T suppressor cell was increased in patients with SRNS in acute relapse (group I, II) in patients in remission on long-term prednisone therapy (group IV) patients and with NS of recent onset (group V) when compared to normal controls (p<0.005), 4) T,/T, ratio was decreased in patients with SRNS in acute relapse (group I, II), in patients with ephrotic syndrome of recent onset (group V) and in patients in remission on long-term prednisone therapy (group IV) when compared to normal controls (p<0.005). We conclude that abnormal T cell subsets are associated with the etiology of SRNS.