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| 루푸스 신염의 임상적 연구 |
| 김원 , 곽재용 , 이창환 , 박성광 , 강성귀 |
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| Abstract |
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Objectives: Systemic lupus erythematosus (SLE) is a multisystem inflammatory disorder characterized by the production of antibodies that react with many different self-antigens. Lupus nephritis has long been consid- ered one of the most ominous components of SLE. The extreme diversity of the renal changes indicates that many variables are likely to be involved. So lupus nephritis is characterized by various chlinicl course, histologic and immunologic patterns. So, we evaluated the clinical characteristics of 32 lupus nephritis patients in Chonbuk National University Hospital. Methods: Forty patients whose clinical findings ful- filled The American Rheumatism Association Criteria for SLE were studied between May 1979 and December 1992 in our hospital retrospectively. Results: In 40 systemic lupus erythematosus patients, lupus nephritis occurred in 32 patients (80%). Subjects mean age was 31.2 (18 to 67 years). Three cases were male and 37 cases were female making the male to female ratio of about 1:12.3. The most common renal manifestation was proteinuria and mean GFR (Ccr) is 78.2 ml/min. Renal failure was developed in 4.8% The most common histological finding by renal biopsy was diffuse proliferative glomerulonephritis (70%). In the only steroid therapeutic group, rate of complete remission and no-response rate were 19.0% and 28.6% Respectively. In the steroid and cyclophosphamid combination group, rate of complete remission and no-response were 54.5%, 9.1% respectively. Conelusion: Treatment with prednisolone and cyclo- phosphamide improve the clinical outcome in patients with lupus nephritis, as compared with steroid alone. |
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