|
| Cyclosporin A와 Lovastatin 의 병합 요법시 발생한 횡문근 융해증 3예 |
| 유기동 , 이원영 , 박지원 , 양철우 , 진동찬 , 윤선애 , 윤영석 , 방병기 |
|
|
| Abstract |
|
Lovastatin (Mevacor), HMG-CoA reductase inhibitor, is effective in lowering both total chloesterol and low- density lipoprotein levels with few side effects. Incidence of rhabdomyolysis in patients with CsA and lovastatin is reported in 30%, but has not been reported in Korea. We report three cases of rhabdomyolysis in kidney transplant recipients receiving lovastatin with CsA therapy. Over one year of post transplant period without the evidence of chronic rejection, they received CsA 225-275 mg (average 250 mg) and lovastatin 20 mg was concomitantly used for 11-39 weeks (average 27 weeks). Muscle weakness, pain, and coca-cola colored urine were developed, and we diagnosed rhaMomyolysis with the markedly increased levels of serum LDH, CK, AST, myoglobin and muscle biopsy. Hemodialysis was not necessary. In transplanted patients receiving cyclosporine and lovastatin, close observation is important for early detection of rhabdomyolysis. |
|
PDF Links
Download Citation
