Korean Journal of Nephrology 1993;12(3):304-315.
각종 사구체신염에서의 B및 T-세포에 관한 연구
강종명 , 안명주 , 강경원
Abstract
Abnormal lymphocyte function has been postulated to have a pathogenetic role in glomerulonephritis. We investigated the pathogenetic role of lymphocyte subpopulation in various types of human glomerulone- phritis. We studied peripheral blood lymphocytes of 114 patients with various kinds of glomerulonephritis. Lymphocytes were separated and stained for B-, T-cells, helper T cells and suppressor T ce11s with monoclonal antibodies (CD19, CD3, CD4, CDS) by using double im- munofluorescence technic. The results were as following: 1) CD3 (+) cells were significantly decreased in all types of glomerulonephritis patients studied. 2) In patients with minimal change nephrotoc syn- drome, CD4 (+) cells were increased significantly, CD8 (+) cells were decreased significantly, and CD4/CD8 ratio was increased significantly in the patients with minimal change nephrotic syndrome compared to con- trols. 3) CD4/CD8 ratio was increased significantly in ne- phrotic patieats with minimal change nephrotic syn- drome compared to non-nephrotic patients with minimal change nephrotic syndrome. 4) In IgA nephropathy patients, there was no signifi- cant correlation between diaease activity and T-cell subpopulation. These results suggest that there are intrinsic abnor- malities in the immunoregulatory T-lymphocyte subpopulations in patients with glornerulonephritia Since this numerical imbalance in T-cell subsets reflects the static picture of the patients at a certain point of time, longitudinal studies in homogeneous populations, testing different parameters in each subject is required. And it will be necessary to perfonn functional in vitro tests using the seperated helper and suppressor T-cell subset to understand the real effect of the numerical abnormalities on the immune response.
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