Korean Journal of Nephrology 1993;12(1):10-19.

글리세롤 근주 이후 발생된 가토의 신장조직변화와 연탄가스 폭로후 변화된 가토의 신장조직 소견에 관한 비교 연구

윤성철 , 김홍주 , 김성진 , 김도헌 , 구정완 , 한동선 , 박언휘 , 김성숙

Abstract

Anthracite coal briquette gas is complex, which is made of CO, SONO, and H,S. Each of them has been known to make a its own characteristic pathologic change. Therefore, various pathologic changes have been reported in the Anthractive coal briquette gas poisoning. Particularly, Acute renal failure in the CO poisoning has been one of main topics to many clinicians. Some reserchers presented tissue hypoxia in the early stage of renal damage and rhabdomyolysis in the follow- ing stages for the etiological aspects. However, the exact cause of the damage is not yet well characterized. We exposed 44 house rabbits with anthractite coal briquette gas & glycerol under the acute condition as well as the chronic condition, and we observed patologic changes sequentially in the course of time, so that we tried to elucidate the extent of damage effects of the rhabdomyolysis by morphologically comparing the renal pathologic changes of rabbits caused by anthracite coal briquette gas poisoning with that by rhab- domyolysis. The rhabdomyolysis was induced by injection of 50 9p glycerol intramuscullary. The obtained results were as follows, 1) The glomerulus was relatively well preserved, but the tubular and interstitial change, as congestion, vascu- lar dilatation, edema were severe, and dependent on doses, under the acute exposure of anthracite coal bri- quete gas and glycerol in both. 2) The more severe damages of the kidney was noted in the chronic exposure of anthracite coal briquette gas as compared in the acute exposure, but the recovering change was found in the chronic exposure of glycerol. 3) The severe congestion, vascular dilatation, edema were observed in either of coal gas exposure and glycer- ol, but the inflammatory change with the mononuclear cell infiltration was confirmed in the acute exposure of coal gas, as well as in the chronic exposure of glycerol. 4) The pathologic findings of renal injury after expo- sure of anthracite coal briquette gas and glycerol were different. And so, the rhaMomyolysis was not considered to be the main cause of renal damage, even though it could be the concomitant factor of renal injury.