Korean Journal of Nephrology 1994;13(4):801-809.
신장이식 후보 환자에서 간생검 소견
김현철 , 주일 , 박성배 , 조원현
Abstract
In order to assess the histopathology of the liver disease in potential candidates for renal transplanta- tion, percutaneous liver biopsies were performed in 35 patients with endmtage renal failure before trans- plantation. Indications for liver biopsy were presence of HBsAg in 20(57%) cases, abnormal liver ehemis- tries in 8(23%), positive anti HCV antibody in 6(17 % ) cases, and abnormal ultrasonographic finding of the liver in one(3% ) case. Several histopathologic patterns were found in 35 liver samples.' chronic per- sistent hepatitis 11(31%), normal histology 9(26%), hemosiderosis 7(20), chronic active hepatitis 3(9 %), nonmpecific reactive hepatitis 2(6%), and oth- ers 3(9%). Histologic diagnosis of 20 patients with HBsAg were chronic persistent hepatitis in 8 cases, normal histology in 7 cases, nonspecific reactive hep- atitis 2 cases, chronic active hepatitis in 2 cases, and others in 3 cases. Histologic diagnosis of six patients with anti HCV antibody were chronic persistent hepatitis in 3 cases, chronic active hepatitis in 2 cases and hemosiderosis in one case. Hepatic outcome according to histologic diagnosis in 20 patients who underwent renal transplantation was vsriable. Follow up ranges from 12 to 86 months, one patient developed cirrhosis and died of sepsis, one developed superinfection with HBV and HCV and one patient who had a chronic persistent hepatitis at the time of transplantation developed chronic active hepatitis 6 months after transplanta- tion. We recommend performing liver biopsy in patients who have postive serology for HBV or HCV and ab- normal liver function tests to accurately evaluate the degree of hepatic damage in potential candidates for renal transplantation.
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