Korean Journal of Nephrology 1994;13(4):887-892.

소아의 원발성 IgA신병증

박혜원 , 하일수 , 정해일 , 최용 , 이현순

Abstract

In order to find out differences in clinical and path- ologic features according to mode of onset, 101 chil- dren with IgA nephropathy were classified into three groups,: 1) NRP group(nephrotic range proteinuria, n=21), 2) NS group(nephrotic syndrome, n=17), 3) RGH group(recurrent gross hematuria, n=63). The clinical and pathological findings of the three groups were analyzed. Males predominate over fe- males in RGH group, while female predilection is ob- served in NRP and NS group(p) 0.01). The propor- tion of glomeruli showing segmental sclerosis was higher in NRP group than in RGH group(p<0.03). The proportion of glomeruli showing cresents and dif- fuse, moderate mesangial proliferation was higher in NRP group than in NS and/or RGH group(p<0.01). The incidence of the tubulointerstitial changes was higher in NRP group than in RGH group(p<0.01). IgA deposits on the glomerular capillary walls were found more frequently in NS group than in RGH group(p<0.01). The frequency of abnormalities of glomerular basement membrane and subepithelial/ subendothelial immune deposition was higher in NS group than in RGH group(p<0.01) In conclusion IgA nephropathy is a heterogeneous syndrome and it can be classified into at least three groups with different clinical and pathologic features according to its presentation at onset. Long term fol- low up beyond pediatric age is required for determi- nation of prognosis of those three groups.