Korean Journal of Nephrology 1994;13(3):669-675.
악성 종양과 동반된 면역글로브린 A 신병증 2예
한병근 , 최승옥 , 류정선 , 신승준 , 김효열 , 이광훈 , 정순희
Abstract
IgA nephropathy is characterized by mesangial deposits of IgA on direct immunofluorescence of renal biopsy specimen. Recently, the cases associated with alcoholic liver cirrhosis, connective tissue disease, liver disease, gastrointestinal disease, dermatologic disease, hematologic disease and malignancy were reported. The association of malignant tumors with 2 various glomerulonephritis is well known. The histopathologic finding has mostly been membranous glomeruloneph- ritis in carcinoma, and minimal change glomerulopathy in lymphoma. Other glomerular alterations have been found less often. Usually, the clinical manifestation of paraneoplastic glomerulonephritis has been the nephrotic syndrome. The literature includes some reports in which IgA nephropathy has been described in patients with neoplastic diseases such as bronchial squamous cell carcinoma, laryngeal carcinoma, mycosis fungoides and mucin-secreting adenocarcinoma of lung, stomach, large intestine and pancreas. The relationship between neoplastic disease and IgA nephropathy remains unresolved at present. The importance of searching malignancy in old age should be considered not only in patients with the nephrotic syndrome but also hematuria should be noted in this respect. Authors report two cases of IgA nephropathy associated malignancy, breast carcinoma and thyroid carcinoma, with a review of literatures.
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