Korean Journal of Nephrology 1994;13(1):53-61.
Calcium Gluconate의 투여가 백서 신장에 미치는 영향
정원조 , 고철우 , 구자훈 , 곽정식
Abstract
This experimental study was conducted to determine the effects of mild hypercalciuria, analogue to the absorptive type of human idiopathic hypercalciuria, on rat's kidney. Sprague-Dawley rats weighing approxi- mately 150 gm were used and divided into group I (calcium gluconate intraperitoneally for 7 days), group II (calcium gluconate intraperitoneally for 14 days) and group III (calcium gluconate intraperitoneally for 14 days, followed by resting period of 7 days). Ten percent aqueous solution of calcium gluconate was used at a dose of 1 ml per 100 gm of body weight. Urinary Ca/Cr ratio and 24 hour urinary calcium excretion were measured on day 0, day 7, day 14, and day 21, Rats were sacrificed weekly for the determination of serum calcium, phosphorus and immunoactive parathyroid hormone. Following results were obtained. Mild elevation of serum calcium levels (mg/dl) per- sisted during study period; 10.5±0.2 on day 0, 11.4±0.9 on day 7, 11.0±0.4 on day 14 and 11.9±1.1 on day 21. And 24 hour urinary calcium excretion (mg/day) was significantly increased to 4.38±3.08 on day 7 compared to 1.12±1.08 on day 0, and this elevation persisted until day 14 and 21 (2.90±1.76, 2.20±2.23, respectively) (p<0. 01), and immunoactive PTH and urinalysis were within normal limit throughout the study period. On light microscopic examination, no definie abnormality was seen. However, on electron microscopic examination, abnormalities of renal tubular cells were observed; in group I, mitochondrial changes showed bizarre shape, increased number of granule and decreased matrical density, and basal infolding was decreased, and in group II and III, these changes were more pronounced. In summary, present study demonstrates that hypercalciuria can cause significant damage to renal tubular cells, and therefore it appears that long standing hypercalciuric status such as idiopathic hypercalciuria should be treated and eliminated more aggressively.
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