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| 신증후군 환아에서 요 B2-microglobulin 및 SDS- PAGE 법에 의한 닫백뇨 분석의 의의 |
| 노은석 , 고철우 , 구자훈 , 송경은 |
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| Abstract |
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1determine the significance of these parameters in relation to the responsiveness to the steroid therapy in nephrotic children. Twenty-nine nephrotic children were used as study patients. Out of these, 15 children were diagnosed as MCNS and 5 PGN, and in the remai- ning 9 children, biopsy was not done due to first episode of nephrotic syndrorne. MCNS children were further divided into infrequent relapser(IR), steroid dependant(SD) and infre- quent relapser changed frorn steroid dependent by cytotoxic therapy(IRSD). Pretreatment urinary B-microglobulin level was elevated compared to the values of 2nd, 4th, 8th and 12th week(88.5±65.5 vs 31.6±45.8, 27.9±41.3, 17.29 ±21.82 and 22.7±37.8 mg/gm creatinine). However, there was no significant difference among different groups except in PGN group, in which its value elevated persistently. Pattems of proteinuria analyzed by SDS-PAGE method showed glomerular-selective in 3 and glomerulotubular-nonselective in 26 cases. In summary, present study indicates that the urinary Oz-microglobulin and patterns of proteinuria determined by SDS-PAGE method are not useful indicator for the prediction of steroid responsiveness in children with nephrotic syndrome. |
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