Korean Journal of Nephrology 1996;15(1):85-89.
고혈압가 만성 신부전을 후유증으로 남긴 신증후성 출혈열 1예
윤성노 , 박철휘 , 신영신 , 양철우 , 진동찬 , 김석영 , 최의진 , 장윤식 , 방병기 , 최영진
Abstract
A 42 year-old-male patient admitted with febrile disease for 5 days with nausea, vomiting and oli- guria. Initial peripheral blood cell count revealed markedly left-shifted leucocytosis and thrombocyto- penia and the blood chemistry showed azotemia. We confirmed HFRS (Hernorrhagic fever with renal syndrome) by clinical findings and four-fold increase of Hanta virus antibody by indirect immunofluore- scent technique. After discharge, renal deficit was persisted and hypertension was newly developed. Biopsy findings performed at 15 weeks after dis- charge showed interstitial fibrosis and mononuclear cell infiltration associated with focal tubular atrophy, which were consistent with interstitial nephritis. The kidney size by initial sonography was relatively normal but the sonography at 15weeks after discharge showed lobulated and contracted kidneys. Serum creatinine was persistently elevated, that was 3.26mg/dl at 12 month after discharge and the blood pressure should be controlled with antihypertensive prescription. He absolutely had no previous history of hypertension and renal disease. We concluded that HFRS resulted in chronic renal failure and hypertension in this case.
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