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그레이브스씨 질환 및 Sjogren씨 증후군과 동반된 원위부 신세뇨관성 산증 |
조은주 , 김백선 , 박철휘 , 윤성노 , 진동찬 , 장윤식 , 방병기 |
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Abstract |
Classic distal renal tubular acidosis(type 1 RTA) is a hypokalemic, hyperchloremic metabolic acidosis due to selective defect in distal acidification. Type 1 RTA may be associated with genetic(usually auto- somal dominant) or autoimmune disease, drugs and toxin and various tubulointerstitial diseases. This case report describes a 27 year-old female patient with distal RTA, Sjogren s syndrome and Graves' disease the first case. She had been suffered from muscle weakness and peripheral numbness and was found to have low serum potassium(1.6mEq/L). She was revealed to have 1) distal RTA by NaH- CC4 loading test 2) Sjogrens syndrome by Schi- rmer s test and palate biopsy and 3) Graves' disease by exophthalmometry and autoantibody test, thyroid function test. This is the first case as far as I search that report the association of distal RTA, Sjogren's syndrome, and Graves disease caused by autoimmune mechanism. |
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