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| 장기간 Furosemide를 복용한 환자에서 신석회화를 동반한 급성 간질성 신염 1예 (A Case of Furosemide Induced Acute Interstitial Nephritis) |
| 임국희, 김영옥, 홍순화, 박재명, 윤선애, 김용수, 정은선, 천경아, 방병기 (Kuk Hee Im, Young Ok Kim, Soon Hwa Hong, Jae Myoung Park, Sun Ae Yoon, Yong Soo Kim, Eun Sun Jung, Kyung Ah Chun and Byung Kee Bang) |
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| Abstract |
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Drug-induced acute interstitial nephritis is characterized by renal interstitial inflammatory cell infiltration and commonly presents as acute renal failure. This is caused mainly by methicillin, non-steroidal antiinflammatory drugs, sulfonamide diuretics such as thiazide, but cases induced by furosemide are rare. We report a patient with acute interstitial nephritis causing reversible acute renal failure and dermatitis while she was taking furosemide. A 37-year old woman was referred to our hospital because of generalized skin rash and non-oliguric acute renal failure. She had peripheral eosinophilia (1,577/mm3) and serum creatinine level of 6.8mg/dL. Skin biopsy showed leukoclastic vasculitis and percutaneous renal biopsy showed severe interstitial infiltration of lymph ocyte and mild interstitial fibrosis with focal tubular atrophy. After withdrawal of furosemide, renal function and skin lesions were completely recovered. |
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