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| 고나트륨혈중의 임상적 특성 (Clinical Characteristics of Hypernatremia) |
| 김정훈, 전은실, 한진석, 양재석, 이서진, 허우성, 이종호, 안규리, 김성권, 이정상 (Jeong Hoon Kim, Un Sil Jeon, Jin Suk Han, Jae Seok Yang, Seo Jin Lee, Curie Ahn, Suhnggwon Kim, Jung Sang Lee, Woo Seong Huh and Jong Ho Lee) |
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| Abstract |
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Hypematremia is a rare but important medical condition and is associated with mortality rate of 40 to 70%. However, little has been known about its prognostic factors or treatment guidlines. To evaluate the prognostic factors and the outcome following treatment, we reviewed 22 available medical records among twenty five hypernatremic patients(0.2%) in 12841 admissions at medical ward from January to December 1995. We defined hyper-natremia as serum sodium concentration more than or equal to 150mEq/L. Of these patients, two had hypematrernia at admission and the remaining patients became hypernatremic during admission. Mean peak serum sodium concentration was 158(150-178) mEq/L and mean total body water deficit was 11.4 (6.7-21.3)%. Factors correlated with the development of hypernatremia were diverse and multiple, and the most frequent factor was diminished access to water. Mortality rate was 59%, but mortality was not correlated with age, correction rate of hyper- natremia, primary route of fluid loss, and the severity of hypernatremia or total body water deficit. Mortality rate was higher in patients whose serum sodium concentrations were below 130mEq/L at admission(P<0.05). In our study, development of hypernatremia from initial hyponatremic state was significantly associated with poor outcome, and age, rapidity of correction, route of fluid loss, and the severity of hypernatremia or total body water deficit were not. |
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