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| 혈액투석시 투석액태 내독소 (endotoxin )농도의 변화 |
| 강원택 , 이병철 , 이경석 , 김원 , 박성광 , 강성귀 |
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| Abstract |
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Endotoxin is a component of bacterial outer mem- brane. Endotoxin is generally a heat-stable toxin that has the various biological activities such as pyrogenicity, macrophage and complement activation. To determine the source of endotoxin contamina- tion in our water processing and dialysate-delivery system in Korea, endoxin was monitored in tap water at the inlet of water softening, in processed water, at the inlet of dialysate proportioner and in the dialysate at the inlet and outlet of the dialyzer. The endotoxin levels were 24.9ng/ml at the inlet of water softening and 2.3mg/ml in processed water. The removal rate of endotoxin during water proces- sing is 90.7%. Endotoxin concentration were 3.58mg/ rnl at the inlet of dialyzer and 12.4mg/ml at the outlet of dialyzer. There was no statistically signifi- cant change between the inlet of dialyzer and the outlet of dialyzer. These result suggested that a reverse-osmosis system appeared necessary for decreasing endotoxin in tap water to a certain eoncentration, so the level of endotoxin in the dialysate would be minimal. |
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