|
| 항사구체 기저막 항체에 의한 급속 진행성 사구체신염 1예 |
| 이승원 , 정연실 , 김필운 , 최지호 , 김태석 , 차미경 , 이종호 , 하승연 , 박문향 |
|
|
| Abstract |
|
Anti-glomerular basement membrane antibody me- diated rapidly progressive glomerulonephritis(anti- GBM antibody mediated RPGN) is defined by the clinical picture of renal failure developing over days or weeks and the histological appearance of crescents and linear immune deposits mediated by the circulating autoantibodies. We report a case of anti-GBM antibody mediated RPGN with review of literature. A 59-year-old female patient was ad- mitted to the Chungang Gil Hospital because of fever and acute deterioration of renal function. On admission, hemoglobin was 7.39g/dL, hematocrit was 20.9%, and BUN/Cr were 39.7 and 5.23mg/dL respec- tively. Urinalysis showed albumin (1+) with many RBCs. Renal biopsy revealed the presence of seg- mental or circumferential cellular crescents asso- ciated with smooth linear staining of glomerular basement membrane with antibody to IgG. High titer of circulating antibody to glomerular basement mem- brane antigen was demonstrated by the ELISA. High doses of corticosteroid with plasmapheresis were administered, but her renal function was pro- gressively deteriorated. |
|
PDF Links
Download Citation
