Korean Journal of Nephrology 1999;18(3):428-435.

99mTc-DMSA 신티그램을 이용한 병적단일신의 임계신기능 평가 (Evaluation of Critical Function in Pathologic Solitary Kidneys Using 99mTc-DMSA Scintigram)

문태용, 김병수, 이석홍, 이준우, 이종화, 곽임수, 정문기 (Tae Yong Moon, Byung Soo Kim, Suck Hong Lee, Jun Woo Lee, Jong Wha Lee, Ihm Soo Kwak and Moon Kee Chung)

Abstract

Objective:To make decision of the dialysis or transplantation in the patient with renal failure should be demanded the precise measurement serving the critical level of the renal function. 99mTc- DMSA is a new renal scanning agent that provides a good quality of renal image as a result of preferential cortical accumulation and also makes feasible a quantitative assessment of renal function. We want to know the critical level of the renal function with 99mTc-DMSA scanning in the experimental rabbits with pathologic solitary kidney. Materials and Methods:We made artificial left hydronephrosis having left ureter ligation at 2 weeks after performing right functional nephrectomy with vessels ligation in 20 experimental rabbits. At 24, 48, and 72 hours after then, 99mTc-DMSA renal uptake rates, serum urea nitrogen, and creatinine were checked to evaluate the critical levels of renal function impairment. Results:Before left ureteral ligation 99mTc- DMSA renal uptake rates, serum urea nitrogen, and creatinine were 9.59±1.14%(mean±SD), 28.0±5.2 mg/dl, and 1.3±0.2 mg/dl respectively. Those of the fifteen pathologic solitary kidney at 24 hours after ureter ligation were 4.37±1.68%, 74.2±20.2mg/dl, and 7.6±2.4mg/dl respectively. Those of the thirteen at 48 hours were 4.25±1.09%, 126.0±33.5mg/dl, and 9.8±3.5mg/dl respectively. And serum urea nitrogen and creatinine of the twelve at 72 hours were 183.9±51.0mg/dl, and 14.4±2.3mg/dl respectively. 99mTc- DMSA renal uptake rates appeared indiscriminate values with approaching to death while the levels of serum urea nitrogen and creatinine revealed increasing values. Conclusion:99mTc-DMSA renal scan was one of the appropriate tests to evaluate the critical level of renal function impairment.