Korean Journal of Nephrology 2000;19(6):1159-1162.

경구 Acyclovir를 투여 중인 환자에서 급성신부전을 동반한 급성 간질성 신염 1예 (A Case of Acyclovir Induced Acute Interstitial Nephritis)

백지연(Jee Yeon Baek),김은일(Eun Il Kim),김영옥(Young Ok Kim),최윤석(Yoon Suk Choi),서정필(Jung Pil Seo),김정선(Jung Sun Kim),윤선애(Sun Ae Yoon),방병기(Byung Gee Bang)

Abstract

Acyclovir is a remarkably safe drug with potent antiviral effect against herpes virus. The two most serious adverse effects are neurotoxicity and nephrotoxicity. We here report the case of a 64-year old woman with acyclovir induced acute interstitial nephritis. She developed non-oiliguric acute renal failure following the administration of oral acyclovir(800mg five times per day) to treat herpes zoster of left 2nd and 3rd thoracic nerves. We documented a normal serum creatinine level just before exposure to the drug. On admission, serum creatinine level was 2.4mg/dL(baseline levei; 0.8mg/dL). Percutaneous renal biopsy revealed interstitial infiltration of lymphocyte and eosinophil with interstitial edema, but there was no crystal formation in the tubules or collecting ducts. After withdrawal of the acyclovir, renal function returned to normal within 1 week.