Korean Journal of Nephrology 2001;20(2):180-186.
원저 : 만성신부전 환자에서 장기간 투석요법 전후의 Insulin-like Growth Factor 및 Insulin-like Growth Factor Binding Proteins 의 변화 (The Changes of Growth Hormone, Insulin-like Growth Factor-1 and Insulin-like Growth Factor Binding Protein-3 Levels after Long-Term Dialysis Therap
이경훈(Kyoung Hoon Lee),문치영(Chi Young Moon),김원(Won Kim),이대열(Dae Yeol Lee),박성광(Sung Kwang Park),강성귀(Sung Kyew Kang)
Abstract
The insulin-like growth factor-I(IGF-I) is a hormone that has growth stimulation and metabolic effects. Insulin-like growth factor binding proteins (IGFBPs) were known to be the most important factors that affect bioavailability of IGF. Thereby, the changes of IGFBPs may affect the bioavailability of IGF-I. Because growth hormone/IGF system may be affected by dialysis therapy, the changes of GH, IGF-1, IGFBPs levels after dialysis therapy can affect the bioavailability of IGF. To evaluate the changes of serum levels of IGF-I and IGFBP-3 after long-term dialysis therapy, we measured the serum IGF-I and IGFBP-3 levels in the patients on hemodialysis and on peritoneal dialysis. Eight: patients undergoing peritoneal dialysis, 10 patients undergoing hemodialysis, and age-matched 10 normal control patients were studied. In patients on hemodialysis, the mean serum level of IGF-I before hemodialysis was 90.6±9.0ng/mL, and after long-term hemodialysis was 130.9±31.0ng/ mL. The mean serum level of IGFBP-3 before hemodialysis was 14,549±7,815 μg/L, and after longterm hemodialysis was 5,726±883 μg/L. There were no significant changes of serum IGF-I and IGFBP-3 levels after long-term hemodialysis therapy. In patients on peritoneal dialysis, the mean serum level of IGF-I before peritoneal dialysis was 169.8±20.5ng/ mL, and after long-term peritoneal dialysis was 242.6±37.6ng/mL. The mean serum level of IGFBP- 3 before peritoneal dialysis was 10,272±885 μg/L, and after ling-term peritoneal dialysis was 8,604±1,721 μg/L. There were no significant changes of serum IGF-I and IGFBP-3 levels after long-term peritoneal dialysis. We found that the level of IGF-1 before hemodialysis was lower then that of normal control group and the level of IGFBP-3 before hemodialysis or peritoneal dialysis was higher then that of normal control group. Our results suggested that the blood levels of growth hormone, IGF-I and IGFBP-3 may not be significantly affected by long-term dialysis therapy.
TOOLS
METRICS Graph View
  • 530 View
  • 19 Download
Related articles


ABOUT
BROWSE ARTICLES
EDITORIAL POLICY
FOR CONTRIBUTORS
Editorial Office
#301, (Miseung Bldg.) 23, Apgujenog-ro 30-gil, Gangnam-gu, Seoul 06022, Korea
Tel: +82-2-3486-8736    Fax: +82-2-3486-8737    E-mail: registry@ksn.or.kr                

Copyright © 2025 by The Korean Society of Nephrology.

Developed in M2PI

Close layer