Korean Journal of Nephrology 2001;20(2):277-282.

원저 : 단백뇨를 가진 IgA 신증 환자들에서 안지오텐신 II 수용체 길항제의 효과 (Effect of Angiotensin II Receptor Blockers in Proteinuric IgA Nephropathy)

노정현(Jueng Hyeun Noh),황유철(You Cheol Hwang),이태원(Tae Won Lee),임천규(Chun Gyoo Ihm)

Abstract

Whether immunosuppressive therapy may have beneficial effects in the treatment of IgA nephropathy remains controversial. ACE inhibitor or angiotensin II receptor antagonist(AIIA) are suggested to reduce urinary protein excretion(Up) in patients with renal diseases. We therefore investigated the effects of the angiotensin II receptor antagonist losartan on the proteinuria and renal function in patients with IgA nephropathy. AIIA reduced blood pressure in patients with hypertension, but there were no significant differences statistically before and after therapy. AIIA reduced Up after 1-4 months(2.8±1.1 to 1.1± 1.0g/24h, p=0.001) and 7-13 months(2.8±1.1 to 1.7±0.6g/24h, p=0.017). There were no significant changes of serum creatinine levels after AIIA treatment. Cough or angioedema were not observed during AIIA treatment. In conclusion, AIIA may be useful in the treatment of patients with IgA nephropathy and proteinuria.