Korean Journal of Nephrology 2002;21(1):178-184.
증례 : POEMS 증후군에 동반된 사구체신염 1 예 (Case reports : A Case of Glomerulonephritis Associated with POEMS Syndrome)
이현순(Hyun Soon Lee),탁우택(Woo Teak Tak),박영아(Young Ah Park),윤성철(Sung Chul Yoon),김종완(Jong Wan Kim)
Abstract
A POEMS syndrome (polyneur opathy, organomegaly, endocr inopathy, monoclonal M protein, and skin lesion) is a rare multisystem disease of unknown cause with varying clinical manifestations. POEMS-associated renal disease is also a rare condition. We experienced a 42-year-old male who had been suffered from generalized edema, low extremity weakness and pain. He also had a significant hematuria, proteinuria, azotemia, hepatospenomegaly, intraperitoneal lymph node enlargement , hypothyroidism, IgA λtype monoclonal gammopathy, specific skin change and ascites. In renal biopsy, membranoproliferative features with enlarged glomeruli, mesangial proliferation, capillary wall thickening and paucity of immune deposit was noted. We suppose that renal insufficiency could come from POEMS syndrome. His symptoms such as low extremity pain, azotemia and generalized edema were improved by hemodialysis and use of prednisolone. At present, he is under the treatment of prednisolone and melphalan. (Korean J Nephrol 2002;21(1) :178-184)
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