Korean Journal of Nephrology 2007;26(2):204-211.
Original Article : Association with Left Ventricular Diastolic Function Parameters and Right Brachial-ankle Pulse Wave Velocity in Hemodialysis Patients
Je Lee, M.D., Seok-Hwan Kim, M.D. Duk-Joo Lee, M.D., Oh Wan Kwon, M.D,Jinho Shin, M.D., Ban Hun Lee, M.D., Jae Ung Lee, M.D., Soon Gil Kim, M.D,Sang-Woong Han, M.D. and Ho-Jung Kim, M.D
Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea
임상연구 : 투석 환자에서 상완족관절 맥파속도와 승모판 혈류 속도에 의한 좌심실 이완기능 지표와의 상관관계
이 제
한양대학교 의과대학 내과학교실
Arterial stiffness is a major independent risk factor for cardiovascular morbidity and mortality in hemodialysis patients. It is hypothesized that arterial stiffness factor is attributable to the structural and functional changes of left ventricle (LV) caused by increased cardiac workload. So we investigated the relationship between brachial-ankle pulse wave velocity (baPWV) and diastolic dysfunction of left ventricle using echoardiographic transmitral blood flow pattern.
For 96 subjects (48 control patients, 48 hemodialysis patients), baPWV and echocardiographic indices for diastolic function, i.e. transmitral E, A, E/A, DT, IVRT were measured just before hemodialysis session. Role of baPWV was tested in a multiple regression model including age, gender, body mass index, predialysis blood pressure, heart rate, LV mass index and interdialysis weight gain.
In the control group, LV mass index (β=-0.350)and rbaPWV (β=-0.403) had an independently correlation with E/A ratio. Rt-baPWV was independently correlated with DT (β=-0.410) and IVRT (β=0.500). In the hemodialysis group, systolic blood pressure (β=-0.389) and heart rate (β= -0.403) were the factors of E/A ratio. Rt-baPWV (β=-0.557) was the factor determining E/A ratio only in female hemodialysis patients.
PWV is independently correlated with E/A ratio only in female hemodialysis patients.Their relationship is limited or weak compared to normal control group. Key Words : Left ventricular function, Hemodialysis, Compliance
Key Words: Left ventricular function, Hemodialysis, Compliance

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