Korean Journal of Nephrology 2007;26(2):212-219.
Original Article : Brain Natriuretic Peptide (BNP), N-terminal pro-BNP (NT-proBNP) and Cardiac Troponin T (cTnT) as Markers of Cardiac Diseases in Stable Hemodialysis Patients
Hyunjeong Baek, M.D.3, Jung Ah Kim, M.D.4, So-Yeon Choi, M.D.1, Yeon-Sil Do, M.D1,Eun-Hee Jang, M.D.1, Jung In Kim, M.D.1, Jung Ho Do, M.D.1, Sung Chul Choi, M.D1,Jung Eun Lee, M.D.1, Wooseong Huh, M.D.1, Dae Joong Kim, M.D.1, Ha-Young Oh, M.D.1,Seung Woo
Department of Medicine1 and Laboratory Medicine2
Samsung Medical Center Sungkyunkwan University School of Medicine; Department of Medicine, Kangwon National University School of Medicine3
Dongin Internal Medicine Clinic4
Seoul, Korea
임상연구 : 혈역학적으로 안정된 혈액투석환자에서 심장 질환 지표로서 B-type Natriuretic Peptide (BNP), N-terminal pro-BNP Cardiac Troponin T 측정
성균관대학교 의과대학 삼성서울병원 내과1, 진단검사의학과2, 강원대학교 의과대학 내과학교실3, 송파 동인내과4
The prevalence of coronary artery disease and left ventricular hypertrophy (LVH) is higher in patients with chronic kidney disease (CKD) than in the general population. In the general population, BNP, NT-proBNP, and cTnT are useful markers of cardiac disease. Recently, studies on biomarkers in patients with CKD have been reported. However, the effect of renal disease on these markers is still uncertain particularly in hemodialysis patients. We investigated the potential of BNP, NT-proBNP, and cTnT as biomarkers of cardiac disease in hemodialysis patients.
We prospectively studied 27 hemodialysis patients without cardiovascular event within the last 6 months. We performed an echocardiography and blood samples for plasma BNP, NT-proBNP and cTnT.
Median BNP, NT-proBNP, and cTnT level (pg/mL) were 433, 10,598, and 0.021, respectively. NT-proBNP was correlated with BNP (r=0.940, p=0.000) and cTnT (r=0.504, p=0.009). There was a negative correlation between BNP and left ventricular ejection fraction (LVEF) (r=-0.502, p=0.008), between NT-proBNP and LVEF (r=-0.556, p=0.003), and between cTnT and LVEF (r=-0.513, p=0.007). There was a positive correlation between BNP and LV mass index (LVMI) (g/m2) (r=0.619, p=0.001). Also, a positive correlation between NT-proBNP and LVMI was shown (r=0.718, p=0.000). There was an insignificant positive correlation between cTnT and LVMI (r=0.369, p=0.063). Albumin, cholesterol, LDL-cholesterol, and NT-proBNP had an independent effect on LVEF (R2=0.80). Age, body mass index, LDL-cholesterol, NT-proBNP, and cTnT had an independent effect on LVMI (R2=0.78).
BNP, NT-proBNP, and cTnT may be as a noninvasive diagnostic or prognostic marker of cardiac disease in stable hemodialysis patients. Key Words : Hemodialysis, Natriuretic peptides, Troponin
Key Words: Hemodialysis, Natriuretic peptides, Troponin
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