| Original Article : Significance of Peritoneal Albumin Excretion in New Peritoneal Dialysis Patients |
| Young-Hwan Hwang, M.D.1, Ju-Young Moon, M.D.2, Hyun-Hee Na, M.D.3, Ki-Won Kim, M.D.4,Seong-Gyun Kim, M.D.5, Ji-Eun Oh, M.D.5, Woo-Kyung Chung, M.D.6, Hyun-Jin Kang, M.D.4,Curie Ahn, M.D4. and Kook-Hwan Oh M.D.4 |
Eulji Medical Center1
Department of Nephrology2
College of Medicine, Kyunghee University Inje University Seoul Paik Hospital3
Division of Nephrology, Department of Internal Medicine4 College of Medicine, Seoul National University, Department of Internal Medicine5
Hallym University Department of Internal Medicine6
Gil Medical Center, Gachon University |
| 임상연구 : 복막투석 초기 환자에서 복막을 통한 알부민 소실량의 의미 |
| 황영환1 |
| 을지병원 신장내과1, 경희대학교 의과대학 내과학교실2, 인제대학교 서울백병원3, 서울대학교 의과대학 내과학교실4,한림대학교 신장연구소 및 내과학교실5, 가천의대 길병원 내과학교실6 |
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| Abstract |
Purpose
High peritoneal transport status is known to be related with the cardiovascular risk. One of the hypotheses that explain the relationship between peritoneal permeability and atherosclerosis is chronic inflammation and endothelial dysfunction. Microalbuminuria is a well-known marker of endothelial dysfunction and a predictor of cardiovascular disease (CVD). We hypothesized that peritoneal albumin excretion, like microalbuminuria, may be related to the cardiovascular events and chronic inflammation in peritoneal dialysis (PD) patients.
Methods
We enrolled eighty-five patients who started PD. Pre-existing CVD was defined as angina, history of MI, cerebrovascular disease, or peripheral arterial disease. Modified peritoneal equilibration test was performed within 2 months. At that time, peritoneal albumin excretion, serum and dialysate IL-6, CRP were measured.
Results
The age was 49.5±14 years and male-to-female ratio was 1 to 3. Diabetes mellitus and CVD were present in 40% and 28%, respectively. The dialysate-to-plasma albumin (D/Palb) was correlated with D/P4 Cr (r= 0.552, p<0.001), and was higher in HA/H group than in LA/L group (0.19±0.008 vs. 0.12±0.005, p<0.001). D/Palb was closely correlated with the dialysate IL-6 (r=0.432, p< 0.001), but not with the serum IL-6 and CRP. There were no differences in the peritoneal albumin excretion with
respect to the diabetic status or pre-existing CVD.
Conclusion
The peritoneal albumin excretion was associated with peritoneal small solute transport and dialysate IL-6 in the new PD patients.
Prospective studies will follow in order to verify the role of peritoneal albumin excretion as a predictor of cardiovascular events.
Key words : Peritoneal dialysis, inflammation, cardiovascular disease |
| Key Words:
Peritoneal dialysis, inflammation, cardiovascular disease |
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