Korean Journal of Nephrology 2007;26(1):61-69.
Original Article : Clinicopathologic Study on Adults Idiopathic Nephrotic Syndrome in Korea
Jung Hoon Sung, M.D., Eun Ah Hwang, M.D., Kyu Bok Jin, M.D., Jin Ho Kwak, M.D. Seung Yeup Han, M.D., Sung Bae Park, M.D. and Hyun Chul Kim, M.D
Department of Internal Medicine, Keimyung University School of Medicine and Dongsan Kidney Institute, Daegu, Korea
임상연구 : 성인 특발성 신증후군의 임상적 고찰 - 단일 기관 성적 -
계명대학교 의과대학 내과학교실, 신장연구소
We examined the clinical characteristics and incidence of adults idiopathic nephrotic syndrome(NS) according to pathologic diagnosis, age, sex.
We retrospectively reviewed the clinical and pathological characteristics of primary glomerular lesions in adults idiopathic NS taken a renal biopsy from 1978 to 2005 at the Dongsan Medical Center. We compared the prevalence of adults idiopathic NS according to the pathologic diagnosis between two time intervals 1978 to 1990 and 1991 to 2005.
The patients had mean age of 36.7±16.3 years and male to female ratio was 1.7:1 with malpredominance. The frequency of histopathologic diagnoses were minimal change nephrotic syndrome(MCNS) 51.6%, membranous glomerulonephritis (MGN) 21.3%, focal segmental glomerulosclerosis (FSGS) 12.1%, IgA nephropathy 9.1%, membranoproliferative glomerulonephritis (MPGN) 4.2% in decreasing order of frequency. The mean age was youngest in MCNS (32.9±15.1) and oldest in MGN(46.2±16.6). Between 1978 to 1990 period and 1991 to 2005 period, the prevalence of MGN was significantly increased, whereas the prevalence of MPGN was decreased significantly. The prevalence of MCNS had a tendency to decrease and that of IgA nephropathy had a tendency to increase, however, both didn't reach statistical significance. The incidence of FSGS didn't show a significant change during the both study periods.
MCNS was the most common disease among adults idiopathic NS. MGN was the most frequent etiology in patients older than 45 years. The incidence of MGN was increased over the 28-year period, and that of MPGN decreased significantly. There was no change in the frequency of FSGS. Key Words : Minimal change nephrotic syndrome, Focal segmental glomerulosclerosis, Membranoproliferative glomerulonephritis
Key Words: Minimal change nephrotic syndrome, Focal segmental glomerulosclerosis, Membranoproliferative

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