| The Effect of Uric Acid on GFR in Early Period after Kidney Transplantation |
| Kim, M.D.1, 3, Jung Tak Park, M.D.1, 3, Tae Ik Chang, M.D.1, 3, Tae-Hyun Yoo, M.D.1, 3, Beom Seok Kim, M.D.1, 3, Shin-Wook Kang, M.D.1, 3, Ho Yung Lee, M.D.1, 3, Dae-Suk Han, M.D.1, 3, Myoung Soo Kim, M.D.2, 3, Soon Il Kim, M.D.2, 3 and Kyu Hun Choi, M.D. |
Department of Internal Medicine1 & Department of Surgery2
The institute of Kidney Disease3
College of Medicine Yonsei University, Seoul, Korea |
| 임상연구 : 신이식 환자에 있어서 이식 초기의 요산 수치와 사구체 여과율 변화량과의 관계 |
| 박선영1, 3, 김동기1, 3, 장제현1, 3, 김현욱1, 3, 김은영1, 3, 박정탁1, 3, 장태익1, 3, 유태현1, 3, 김범석1, 3, 강신욱1, 3, 이호영1, 3, 한대석1, 3, 김명수2, 3, 김순일2, 3, 최규헌1, 3 |
| 연세대학교 의과대학 내과학교실1, 외과학교실2, 신장질환 연구소3 |
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| Abstract |
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Purpose : Hyperuricemia is a common complication occurring shortly after kidney transplantation. Although increased uric acid level is a risk factor for cardiovascular disease and mortality, the relationship between uric acid level and graft function after transplantation has been a controversial issue. Therefore, we investigated the effects of uric acid on glomerular filtration rate (GFR) and graft survival in the early periods of kidney transplantation.
Methods : Data were collected from 245 patients who underwent kidney transplantation between 2002 and 2004 at Yonsei University Medical Center. Uric acid level and estimated GFR were measured monthly during the first 6 months and then yearly for 3 years.
Results : The mean age of the study population was 40.2±11.7 years. The proportion of patients with hyperuricemia (uric acid ≥6.8 mg/dL) showed increment during the 3 year follow up. Increased serum uric acid level showed a negative correlation with estimated GFR during the initial 6 months after transplantation (r=-0.026, p<0.05). In Kaplan-Meier analysis, patients with a mean uric acid level higher than 6.8 mg/dL during the first 6 months showed a lower cumulative graft survival during the consecutive 3 years compared to patients with a uric acid level lower than 6.8 mg/dL (HR 1.7, p=0.003).
Conclusion : Uric acid levels were associated with the changes of GFR in the initial 6 months of kidney transplantation, and the hyperuricemia during the early stages of transplantation might influence the long term graft survival.
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| Key Words:
Uric acid, Kidney transplantation, Glomerular filtration rate |
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