IgA Nephropathy Encountered in a Patient with Hodgkin Lymphoma

Korean Journal of Nephrology 2008;27(6):720-725.

Changyoung Yoo, M.D., Yeong-Jin Choi, M.D., Sang In Shim, M.D. and Kyoyoung Lee, M.D.

Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea

증례 : IgA Nephropathy Encountered in a Patient with Hodgkin Lymphoma

Changyoung Yoo, M.D., Yeong-Jin Choi, M.D., Sang In Shim, M.D. and Kyoyoung Lee, M.D.

Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea

Abstract

Various types of glomerulonephritis can occur at the same time with Hodgkin lymphoma, including minimal change disease and membranous glomerulonephritis. However, the concurrence of IgA nephropathy with Hodgkin lymphoma is rare. We report here on a case of IgA nephropathy in a patient with newly diagnosed Hodgkin lymphoma: A 60-year-old man presented with weight loss and anorexia. The patient showed lymphadenopathies in the neck on physical examination, and multiple lymphadenopathies in the mediastinum and abdomen on computerized tomography. Diagnosis of Hodgkin lymphoma was made after cervical lymph nodes were excised, but during the course of the chemotherapy, laboratory findings of hematuria and an elevated creatinine level were observed and IgA nephropathy was additionally diagnosed from a renal biopsy. There were fluctuations in the creatinine level and the amounts of hematuria and proteinuria, but by the time of the eighth cycle of chemotherapy, the patients condition had rapidly deteriorated, mainly due to the newly developed adult respiratory distress syndrome. The patient died soon thereafter.

Key Words: Uric acid, Kidney transplantation, Glomerular filtration rate