A Case of Membranoproliferative Glomerulonephritis Associated with Sjögren's Syndrome

Korean Journal of Nephrology 2008;27(4):508-512.

Ssang Yong Oh, M.D.1, Hee Jeong Cha, M.D.2, Min Su Kim, M.D.1, Hyun Cho, M.D.1, Hyun Chul Chung, M.D.1, Jong Soo Lee, M.D.1 and Jongha Park, M.D.1

Department of Internal Medicine1 and Pathology²
Ulsan University Hospital University of Ulsan College of Medicine, Ulsan, Korea

증례 : 쇼그렌 증후군에 동반된 막증식성 사구체신염 1예

오쌍용1, 차희정2, 김민수1, 조현1, 정현철1, 이종수1, 박종하1

울산대학교 의과대학 울산대학교병원 내과학교실1, 병리학교실2

Abstract

Sjögrens syndrome is a slowly progressive autoimmune disease characterized by lymphocytic infiltration of the exocrine glands, resulting in the xerostomia and xerophthalmia. In this syndrome, renal involvement includes interstitial nephritis, clinically manifested by hyposthenuria and renal tubular dysfunction with or without acidosis. Glomerulonephritis, however, is a rare finding and there have been few reports of membranous glomerulopathy or membranoproliferative glomerulonephritis (MPGN). We report a 31-year-old female diagnosed as MPGN associated with primary Sjögren's syndrome. She suffered from recurrent epigastric pain, and revealed a moderate proteinuria. Renal biopsy findings were consistent with type I MPGN and thereafter Sjögren's syndrome was diagnosed by further evaluation. She did not meet the criteria to systemic lupus erythematosus or other connective tissue disease. To our knowledge, this is the first report of MPGN associated with Sjögrens syndrome in Korea.

Key Words: Membranoproliferative glomerulonephritis, Proteinuria, Sjögrens syndrome, Vasculitis