Korean Journal of Nephrology 2008;27(4):513-517.
Selective Proximal Tubule Injury and Progressive Renal Failure due to Ifosfamide and Cisplatin in a Patient with Ovarian Cancer
Su Hyun Kim, M.D.1, Sung Min Nam, M.D.2, Hye Eun Yoon, M.D.2, Yong Kyun Kim, M.D.2, Eun Young Park, M.S.3 , Wan-Young Kim, Ph.D.3, Yong Soo Kim, M.D.2, Jin Kim, M.D.3 , Byung Kee Bang, M.D.2 and Chul Woo Yang, M.D.2
Department of Internal Medicine1
College of Medicine, Chung-Ang University, Departments of Internal Medicine2 and Anatomy3
College of Medicine, The Catholic University of Korea, Seoul, Korea
증례 : Selective Proximal Tubule Injury and Progressive Renal Failure due to Ifosfamide and Cisplatin in a Patient with Ovarian Cancer
Su Hyun Kim, M.D.1, Sung Min Nam, M.D.2, Hye Eun Yoon, M.D.2, Yong Kyun Kim, M.D.2, Eun Young Park, M.S.3 , Wan-Young Kim, Ph.D.3, Yong Soo Kim, M.D.2, Jin Kim, M.D.3 , Byung Kee Bang, M.D.2 and Chul Woo Yang, M.D.2
Department of Internal Medicine1, College of Medicine, Chung-Ang University, Departments of Internal Medicine2 and Anatomy3, College of Medicine, The Catholic University of Korea, Seoul, Korea
Abstract
Ifosfamide-induced nephrotoxicity is usually manifested in the form of Fanconi syndrome and the combination of cisplatin enhances ifosfamide-induced nephrotoxicity. We here report a case of report specific proximal tubular dysfunction and progressive renal failure after ifosfamide and cisplatin chemotherapy in a 32-year old woman with ovarian cancer. The patient was referred to our department due to severe hypokalemia and elevated serum creatinine. Her renal function was abruptly impaired and serum and urine electrolytes were consistent with Fanconi syndrome. The kidney biopsy revealed atrophy and falling of renal tubular cells, and immunohistochemical staining with aquaporin 1 (AQP1) revealed that injured epithelial cells were proximal tubular cells. This finding suggests that ifosfamide selectively impairs proximal tubule function and combination with cisplatin causes progressive renal failure.
Key Words: Ifosfamide, Fanconi syndrome, Renal failure
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