| Acute Renal Failure Complicated by Valaciclovir in a Patient with IgA Nephropathy |
| Jeong Seon Kim, M.D.1, Hye Won Kim, M.D.1 , Jae Won Lee, M.D.1, Hye Min Choi, M.D.1, Sang Won Park, M.D.1, Young Mo Lee, M.D.1, Ji Eun Lee, M.D.2, Young Joo Kwon, M.D.1 and Heui Jung Pyo, M.D.1 |
Division of Nephrology1
Department of Internal Medicine; College of Medicine, Korea University, Seoul, Korea; Department of Internal Medicine2
Wonkwang University, Seoul, Korea |
| 증례 : IgA 신증 환자에서 valaciclovir 복용 중 발생한 급성 신부전 1예 |
| 김정선1, 김혜원1, 이재원1, 최혜민1, 박상원1, 이영모1, 이지은2, 권영주1, 표희정1 |
| 고려대학교 의과대학 내과학교실1, 원광대하교 의과대학 내과학교실2 |
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| Abstract |
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Valaciclovir is L-valyl ester of acyclovir which has the antiviral effect against herpes zoster virus and Cytomegalovirus. Its adverse effects were reported as nephrotoxicity and neurotoxicity. Although the mechanism of nephrotoxicity of valaciclovir is indeterminate, several hypotheses such as obstructive uropathy and interstitial nephritis have been suggested.
We experienced a 54-year-old female patient with IgA nephropathy who developed acute renal failure after taking valaciclovir. She did not develop either central neuropathy or respiratory muscle weakness. The serum creatinine was normalized after 6 days by withdrawal of valaciclovir and hydration. When we use valaciclovir in the elderly or patients with preexisting renal disease, we should monitor the renal function carefully. |
| Key Words:
Valaciclovir, Kidney failure, Acute |
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