Korean Journal of Nephrology 2009;28(6):658-662.
A Case of Chronic Renal Failure in a Polydipsic Schizophrenic Patient caused by Chronic Anticholinergic Therapy
Il Young Chon, M.D., Dong Joon Oh, M.D., Seung-Jin Choi, M.D., Ji-Young Kim, M.D., Keryun Ahn, M.D., Won Joon Lee, M.D., Ji-Yeon Lee, M.D., Haeri Baek, M.D., Eunji Lee, M.D., Sangwon Han, M.D., Chan Bok Lee M.D., Sang Eun Park, M.D. and Byoungkook Im, M.D
Department of Internal Medicine, Sam Anyang Hospital, Anyang, Gyeonggi-do, Korea
증례 : 다음증을 동반한 정신분열증 환자에서 항콜린성 약물 복용 중 발생한 만성 신부전 1례
전일영, 오동준, 최승진, 김지영, 안계련, 이원준, 이지연, 백혜리, 이은지, 한상원, 이찬복, 박상은, 임병국
샘안양병원 내과학교실
Abstract
Anticholinergic drugs block muscarinic receptors at the detrusor muscle of the bladder. It can cause urinary retention by contracting the bladder neck. Cases of hydronephrosis, bladder dilatation as a result of polydipsia while taking anticholinergic drugs have been reported, but very few cases of chronic renal failure can be found. We report a case of a polydipsic schizophrenic patient who, after taking anticholinergic drugs as antipsychotic drugs to treat his schizophrenia for a long time, presented with chronic renal failure due to functional obstructive uropathy in the absence of demonstrable anatomic causes of obstruction.
Key Words: Anticholinergics, Chronic renal failure, Urinary retention


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