| A Case of Post-transplant Lymphoproliferative Disorder Manifested as Native Kidney Mass |
| Ji Youn Yu, M.D.1, Mi Youn Park, M.D.1, Yeon Oh Jeong, M.D.1, Hae Kyung Lee, M.D.2, Ji Chan Park, M.D.1, Sang Ju Lee, M.D.1, Yoon Kyung Chang, M.D.1, Suk Young Park, M.D.1 and Suk Young Kim, M.D.1 |
Department of Internal Medicine1
Department of Pathology2 College of Medicine, The Catholic University of Korea |
| 증례 : 신이식 환자의 기저 신장에 발병한 Post-transplant lympoproliferative disorder (PTLD) 1예 |
| 유지연1, 박미연1, 정연오1, 이혜경2, 박지찬1, 이상주1, 장윤경1, 박석영1, 김석영1 |
| 가톨릭대학교 의과대학 대전성모병원 내과학교실1, 조직병리학교실2 |
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| Abstract |
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Post-transplant lymphoproliferative disorder (PTLD) following solid organ transplantation is an important form of post-transplant malignancy. PTLD is typically associated with Epstein–Barr virus (EBV) and occurs in the setting of immunosuppression resulting in a deficiency of EBV-specific cytotoxic T lymphocytes. PTLD encompasses heterogeneous lymphoproliferative diseases, from polyclonal proliferation resembling infectious mononucleosis to aggressive monomorphic proliferation such as diffuse large B- cell lymphoma. Clinically, PTLD is usually manifested as lymph nodal mass or extranodal mass of solid organs such as liver, transplanted kidney, tonsil, bone marrow or spleen. The authors experienced very rare case of PTLD manifested as a single mass in a native kidney. According to a review of the literature, this is a rare case of PTLD which developed in a native kidney after kidney transplantation. Initially under the impression of renal cell carcinoma, unilateral nephrectomy of the native kidney had performed, and after confirmed as PTLD by histologic diagnosis the patient had treated with reduction of immunosuppressants and chemotheraphy for PTLD, and eventually has got in complete remission. |
| Key Words:
Lymphoproliferative disorder, Kidney transplantation |
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