| The Factors Influencing Level of Advanced Oxidation Protein Products (AOPP) in Hemodialysis Patients |
| Jeong Min Cha, M.D.1, Kang Won Lee, M.D.1, Yu Min Lee, M.D.1, Hyun Jung Kim, M.D.3, Do Sim Park, M.D.2, Seon Ho Ahn, M.D.1 and Ju Hung Song, M.D.1 |
Department of Internal Medicine1
Department of Laboratory Medicine2
Wonkwang University School of Medicine, Iksan, Korea, Department of Internal Medicine3
Kunsan Medical Center of Wonkwang University Hospital |
| 임상연구 : 혈액투석 환자에서 Advanced Oxidation Protein Products (AOPP)의 농도에 영향을 주는 요인 |
| 차정민1, 이강원1, 이유민1, 김현정3, 박도심2, 안선호1, 송주흥1 |
| 원광대학교 의과대학 내과학교실1, 진단검사의학과교실2, 원광대학교 의과대학 군산의료원 내과3 |
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| Abstract |
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Purpose:Advanced oxidation protein products (AOPP) has long been considered as a useful marker to estimate oxidative stress in the hemodialysis (HD) patients. However, it has not been clarified what clinical factors can affect the plasma level of AOPP in the HD patients. Based on these, We investigated the correlation between plasma AOPP level and clinical factor, known to be associated with oxidative stress, in the maintenance HD patients.
Methods:Two groups (50 of normal healthy persons and 105 of stable HD patients) were independently subjected in this study, and statistical correlation between plasma AOPP level and several clinical factors were analyzed.
Results:Plasma level of AOPP in the maintenance HD patients were higher than those in normal healthy group (52.11±16.08 μmol/L vs. 40.25±12.23 μmol/L, p<0.001). Plasma AOPP level of maintenance HD patients were significantly correlated with duration of hemodialysis, MDRD-GFR and daily urine volume. However, plasma level of AOPP in the maintenance HD patients were not affected by sex, diabetes, smoking, angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers, and those were not correlated with age, CRP and serum ferritin. It was demonstrated by multiple regression analysis that daily urine volume was the most important clinical factor which could affect the plasma level of AOPP (beta=-0.255, p=0.017).
Conclusion:These results suggest that maintenance of daily urine volume is likely to be critical to reduce oxidative stress in the maintenance HD patients. |
| Key Words:
Oxidative stress, Dialysis, Maintenance |
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