Korean Journal of Nephrology 2009;28(1):44-48.
Rifampicin-Induced Severe Hyperkalemia Requiring Hemodialysis in a Patient with Addison's Disease
Hyun Gyung Kim, M.D., Yoo Sun Yoon, M.D., Hee Hun Kim, M.D., Young-Soo Kim, M.D., Byung Soo Kim, M.D., Sun Ae Yoon, M.D. and Young Ok Kim, M.D.
Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
증례 : 부신피질 결핵에 의한 Addison씨 병 환자에서 리팜핀 투여 후 혈액투석이 필요하였던 심한 고칼륨혈증 1예
김현경, 윤유선, 김희언, 김영수, 김병수, 윤선애, 김영옥
가톨릭대학교 의과대학 내과학교실
Abstract
Rifampicin, a potent inducer of hepatic microsomal enzymes, increases metabolism of steroid hormone. Therefore, concurrent treatment of rifampicin and steroid may lead to decreased bioavailability and increased requirement of steroid hormone. Here we report a case of rifampicin-induced severe hyperkalemia requiring hemodialysis in a patient with Addison's disease. A 52-year-old woman was admitted due to general weakness. She had been diagnosed with adrenal tuberculosis and consequent Addison's disease and treated with rifampicin and physiologic dose of steroid. Blood chemistry showed 9.1 mEq/L of potassium and emergent hemodialysis was performed. With increment of dosage of steroid hormone and maintenance of the same dosage of rifampicin, potassium level was normalized.
Key Words: Addison's disease, Rifampicin, Glucocorticoid


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