A Case of AA Amyloidosis Treated with Infliximab

Korean Journal of Nephrology 2010;29(5):638-643.

Da Ham Kim, M.D.1, Kyeong Hye Park, M.D.1, Su Hwan Lee, M.D.1, Shin Young Hyun, M.D.1, Jeong Hae Kie, M.D.2, and Ea Wha Kang, M.D.1

Departments of Internal Medicine1 and Pathology²
National Health Insurance Corporation Ilsan Hospital, Goyang, Korea

증례 : AA아밀로이드증에서 Infliximab (RemicadeⓇ ) 치료 1예

김다함1, 박경혜1, 이수환1, 현신영1, 기정혜2, 강이화1

국민건강보험공단 일산병원 내과1 , 병리과2

Abstract

AA amyloidosis is one of the most significant complications of rheumatoid arthritis characterized by the deposition of amyloid A (AA) in multiple organs and tissues in the body. This disorder displays variable clinical symptoms depending upon the involved organ and a diagnosis is rendered through a biopsy of the affected organ, followed by staining using Congo-red which reveals an apple-green birefringence. Fundamental disease control is critical in the treatment of AA amyloidosis. Anti-tumor necrosis factor alpha (anti TNF-α) agents are promising in inducing clinical remission by suppressing systemic inflammation in AA amyloidosis. We report a case of AA amyloidosis in a 71 year old woman with rheumatoid arthritis that responded well to infliximab therapy.

Key Words: Amyloidosis, Rheumatoid arthritis, Infliximab