| Biopsy-Proven Immune Complex Glomerulonephritis Associated with Sunitinib in a Patient with a Gastrointestinal Stromal Tumor |
| Hankyu Lee, M.D.1, Hyang Rim Lee, M.D.2, Kook-Hwan Oh, M.D.2, Kyung Chul Moon, M.D.3, Curie Ahn, M.D.2, Suhnggwon Kim, M.D.2, and Yung-Jue Bang, M.D.1 |
Department of Internal Medicine1
Eulji Hospital, Daejeon Department of Internal Medicine2
Seoul National University College of Medicine Department of Pathology3
Seoul National University College of Medicine |
| 증례 : Biopsy-Proven Immune Complex Glomerulonephritis Associated with Sunitinib in a Patient with a Gastrointestinal Stromal Tumor |
| Hankyu Lee, M.D.1, Hyang Rim Lee, M.D.2, Kook-Hwan Oh, M.D.2, Kyung Chul Moon, M.D.3, Curie Ahn, M.D.2, Suhnggwon Kim, M.D.2, and Yung-Jue Bang, M.D.1 |
| Department of Internal Medicine1, Eulji Hospital, Daejeon Department of Internal Medicine2, Seoul National University College of Medicine Department of Pathology3, Seoul National University College of Medicine |
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| Abstract |
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Sunitinib, a multi-targeted tyrosine kinase inhibitor, is used for the treatment of renal cell carcinoma and gastrointestinal stromal tumors. Many adverse effects associated with sunitinib, including hypertension, proteinuria, and thrombotic microangiopathy, have been reported; however, the other forms of glomerulonephritis are very rare. We report a case of biopsy-confirmed immune complex glomerulonephritis in a patient with a gastrointestinal tumor who received sunitinib treatment. The proteinuria subsided partially after sunitinib was discontinued, but when the drug was reintroduced, it recurred. |
| Key Words:
Glomerulonephritis, Sunitinib, Gastrointestinal stromal tumor |
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