Korean Journal of Nephrology 2010;29(5):650-655.
A Case of Recurrent C1q Nephropathy Treated by Immunosuppressant Combination Therapy
Min Bom Park, M.D.1, Eun Na Kim, M.D.1, Eun Ho Jeong, M.D.1, Jin Ou Kim, M.D.1, Hee Bae Wang, M.D.1, Tae Ho Kim, M.D.1, Key Jo Lee, M.D.1, Sang Yeol Suh, M.D.1 and So young Jin, M.D.2
Department of Internal Medicine1
Seoul Red Cross Hospital, Seoul Korea Department of pathology2
Soonchunhyang University Hospital, Seoul Korea
증례 : 재발한 C1q신병증을 면역억제제 병합요법으로 치료한 1예
박민범1, 김은나1, 정은호1, 김진우1, 왕희배1, 김태호1, 이기조1, 서상렬1, 진소영2
서울적십자병원 내과1 , 순천향대학교 의과대학 병리학교실2
Abstract
The definition of C1q nephropathy has been categorized since 1985. However, the clinical correlation and pathophysiology has not yet been fully revealed. Therefore, the treatment of C1q nephropathy has not been established. Our subject was a 23 year-old female patient with both leg edema and oliguria, who was presented with weight gain. Renal biopsy confirmed C1q nephropathy. Prednisolone and cyclosporine therapy was selected for treatment. After 2 weeks of treatment, the patient lost 8 kg of body weight and all laboratory examination results were normalized. Both leg edema and oliguria were resolved. After 21 weeks of regular follow-up, she stopped the medicine by herself. Eight weeks later, the patient came to the Emergency room because both leg edema recurred. Same regimen was administered for 3 weeks, and complete remission was achieved again.
Key Words: C1q, Prednisolone, Cyclosporine


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