| De Novo Light Chain Deposition Disease in Long-term Survived Renal Allograft |
| Misun Choe, M.D.1, Mihyun Jang, M.D.2, Eunah Hwang, M.D.2, Sang Sook Lee, M.D.1 and Hyunchul Kim, M.D.2 |
Departments of Pathology1 and Internal Medicine2
Keimyung University College of Medicine, Daegu, Korea |
| 증례 : 장기간 생존한 동종이식 신장에서 새로 발생한 경쇄침착병 |
| 최미선1 , 장미현2 , 황은아2 , 이상숙1 , 김현철2 |
| 계명대학교 의과대학 병리학교실1 , 내과학교실2 |
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| Abstract |
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Light chain deposition disease (LCDD) is characterized by the deposition of abnormal immunoglobulin light chains in many organs, including kidney. It is usually associated with multiple myeloma or other lymphoproliferative disorders. Myeloma usually occurs in old age and may develop after renal transplantation thus being categorized as posttransplant lymphoproliferative disease (PTLD). Renal LCDD usually presents with variable degree of proteinuria and renal insufficiency. The diagnosis of LCDD depends on histologic findings with detection of monoclonal immunoglobulin light chain. Histologically, it is characterized by nodular glomerulosclerosis. We report the first case of de novo LCDD associated with myeloma after renal transplantation in Korea. With advancing renal transplantation and increasing old aged renal recipients, myeloma or LCDD should be included in the differential diagnoses of renal recipient patients with deteriorating renal function. |
| Key Words:
Kidney, Transplantation, Immunoglobulin light chain, Myeloma |
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